Stages of experimental epidermal carcinogenesis in the mouse.

The problem of carcinogenesis is an extremely wide and complex one and is unlikely to be solved by one man using one experimental model. On the other hand, it seems preferable to choose one model and explore its possibilities thoroughly before discarding it in the hope that there may be a common denominator to all carcinogenic processes. This thesis will attempt to show that by the use of a well-established experimental model, but by adding newer techniques, new and valuable information can be obtained. The two-stage production of papillomata in the skin of mice was chosen for several reasons. Training in this subject under experienced guidance is available in a favourable university environment. The basic experimental technique has been well established, and much information on it is available