Effect of insulin on hepatic production and peripheral utilization of glucose in normal human subjects; studies with C14-glucose.

Almost forty years have elapsed since the discovery of insulin by banting and best, but its mechanism of action is still far from being completely elucidated. Although the number of relevant publications is steadily increasing, up to the present date no unanimity of scientific opinion exists as to the site of insulin action. Two opposing concepts emerged as a result of investigations. One group of workers considered that the main factor in causing hypoglycemia is the effect of insulin to increase the rate of glucose utilization another school of thought attributed the blood sugar lowering action of insulin to an almost complete cessation of hepatic glucose output