Regioselective Synthesis ofFluorohydrines via SN2-Type Ring-Opening of Epoxideswith TBABF-KHF2

We found that the ring-opening fluorination of terminal epoxidesusing TBABF-KHF2 proceeds with high selectivity throughthe SN2 mechanism. As TBABF-KHF2 iseasily obtainable, is stable, and can be used in glassware, it canbe a useful reagent for 1-fluoro-2-alkanol synthesis from the terminalepoxides