Perfusion-based high-resolution fMRI in the primate brain using a novel vertical large-bore 7 Tesla setup

Obtaining functional CBF maps with high spatial resolution is challenging, because the CBF signal is intrinsically low and the signal-to-noise is critical. Here we report the first high-resolution CBF maps in the Macaca mulatta that were obtained with voxel sizes as small as 0.5x0.5x3 mm3. High sensitivity was achieved by using a 7T system and custom-made RF coils in TORO mode. fCBF data were acquired and compared with BOLD data in the macaque primary visual cortex. The fCBF signal was entirely localized within cortex, providing unequivocal evidence for its high spatial specificity. This specificity is of paramount importance for studies seeking to understand the physiological basis of functional neuroimaging