A novel, local inhibitory circuit in layer 2/3 of rat somatosensory cortex is described that connects pyramidal cells reciprocally with GABAergic vasoactive intestinal polypeptide-immunoreactive bipolar interneurons. In paired whole-cell recordings, the glutamatergic unitary responses (EPSPs or EPSCs) in bipolar cells evoked by repetitive (10 Hz) stimulation of a pyramidal cell show strong frequency-dependent depression. Unitary IPSPs evoked in pyramidal cells by repetitive stimulation of bipolar cells, on average, maintained their amplitude. This suggests that the excitatory synapses on bipolar cells act as a low-pass filter in the reciprocal pyramid-to-bipolar circuit. The EPSCs in bipolar cells are mediated predominantly by AMPA receptor...
1. Glutamate receptor (GluR) channels were studied in basket cells in the dentate gyrus of rat hippo...
1. Currents activated by glutamate receptor (GluR) agonists were recorded from outside-out patches i...
SummaryCortical pyramidal neurons alter their responses to input signals depending on behavioral sta...
A novel, local inhibitory circuit in layer 2/3 of rat somatosensory cortex is described that connect...
A novel, local inhibitory circuit in layer 2/3 of rat somatosensory cortex is described that connect...
International audienceWe have investigated the conditions required to evoke polysynaptic responses i...
At many glutamatergic synapses in the brain, calcium-permeable alpha - amino - 3 - hydro - 5 - methy...
In neocortical circuits, repetitively active neurons evoke unitary postsynaptic potentials (PSPs) wh...
In recent years, considerable progress in our understanding of the molecular events underlying excit...
Many principal neurons undergo an early developmental switch fromGluR2-lacking to GluR2-containing s...
Although GABAergic interneurons are the main source of synaptic inhibition in the cortex, activation...
1. Glutamate receptor (GluR) channels were studied in basket cells in the dentate gyrus of rat hippo...
1. Glutamate receptor (GluR) channels were studied in basket cells in the dentate gyrus of rat hippo...
1. Currents activated by glutamate receptor (GluR) agonists were recorded from outside-out patches i...
SummaryCortical pyramidal neurons alter their responses to input signals depending on behavioral sta...
A novel, local inhibitory circuit in layer 2/3 of rat somatosensory cortex is described that connect...
A novel, local inhibitory circuit in layer 2/3 of rat somatosensory cortex is described that connect...
International audienceWe have investigated the conditions required to evoke polysynaptic responses i...
At many glutamatergic synapses in the brain, calcium-permeable alpha - amino - 3 - hydro - 5 - methy...
In neocortical circuits, repetitively active neurons evoke unitary postsynaptic potentials (PSPs) wh...
In recent years, considerable progress in our understanding of the molecular events underlying excit...
Many principal neurons undergo an early developmental switch fromGluR2-lacking to GluR2-containing s...
Although GABAergic interneurons are the main source of synaptic inhibition in the cortex, activation...
1. Glutamate receptor (GluR) channels were studied in basket cells in the dentate gyrus of rat hippo...
1. Glutamate receptor (GluR) channels were studied in basket cells in the dentate gyrus of rat hippo...
1. Currents activated by glutamate receptor (GluR) agonists were recorded from outside-out patches i...
SummaryCortical pyramidal neurons alter their responses to input signals depending on behavioral sta...