Effect Analysis of Helicobacter Pylori Eradication

目的从幽门螺杆菌(HElICObACTEr PylOrI,H.PylOrI)根治的疗效角度,探讨影响H.PylOrI治疗的可能因素,以期为临床合理用药提供依据。方法对本院2010年1月—2011年9月经胃镜尿素酶检查和(或)13C-呼气试验检测H.PylOrI阳性患者的治疗情况进行随访,收集H.PylOrI治疗结果并进行统计、分析。结果患者资料完整者共502例,H.PylOrI总体根除率为60.76%,其中男性根除率为66.67%(164/246),女性根除率为55.08%(141/256),不同性别H.PylOrI根除率比较,差异有统计学意义(χ2=7.066,P0.05)。本研究筛选出9种不同的H.PylOrI根治方案,其中以质子泵抑制剂(PPI)+铋剂(b)+克拉霉素(C)+左氧氟沙星(l)方案H.PylOrI根除率最高(为80.49%),PPI+b+l+替硝唑(TIn)的H.PylOrI根除率最低(为50.00%),两种方案H.PylOrI根除率比较,差异有统计学意义(χ2=7.570,P0.05)。7 d疗程方案者占63.75%,H.PylOrI根除率为63.44%,较其他疗程高,各疗程间H.PylOrI根除率比较,差异无统计学意义(χ2=3.294,P>0.05)。埃索美拉唑(ESO)与奥美拉唑(OME)方案H.PylOrI根除率比较,差异有统计学意义(χ2=7.839,P=0.005,检验水准调整值为0.008)。结论 H.PylOrI根除率与性别、治疗方案、PPI有关,与年龄、疗程无关。Objective To explore factors that affect the outcomes of Helicobacter pylori(H.pylori) eradication.Methods A total of 502 patients who were confirmed to be with H.pylori infection by Gastroscope urease and/or 13C-UBT in our hospital between January 2010 and September 2011 were enrolled in this study.The relevant data were collected and analyzed.Results The total eradication rate was 60.76%,in which the eradication rate was 66.67%(164/246)in males and 55.08%(141/256)in females(χ2=7.066,P0.05).Among the 9 therapeutic regimens,PPI+B+C+L achieved the highest eradication rate(80.49%),whereas PPI+B+L+Tin had the lowest one(50.00%)(χ2=7.570,P0.05).About 63.75% of the patients applied the 7-day regimen,and the the eradication rate was 63.44%,which was higher than other regimens.The eradication rates showed no statistical difference among different treatment cycles(χ2=3.294,P>0.05).The esomeprazole group and omeprazole group had significantly different H.pylori eradication rates(χ2=7.839,P=0.005).Conclusion The H.pylori eradication rate is related to gender,treatment scheme,and proton-pump inhibitors,but not to age and treatment cycle