Prolongation of Hamster-to-rat Xenograft Survival by Resveratrol and the potential Mechanism

临床上器官功能衰竭终末期进行器官移植是最理想的治疗方法，然而由于供体器官匮乏严重制约了器官移植的发展。异种移植是解决器官匮乏的最佳途径之一。随着基因技术的发展，人们利用基因修饰的方法，将α(1,3)半乳糖基转移酶基因敲除（GalT-KO）并联合转入受体源补体调节蛋白基因（CRPs），从而成功地避免了超级性排斥反应（HAR）的发生。然而对于后续发生的急性体液性异种移植排斥反应(Acutehumoralxenograftrejection，AHXR)、急性细胞性异种移植排斥反应(Acutecellularxenograftrejection，ACXR)、急性血管性排斥反应(Acutevascula...Background and purpose: Several alternatives have been suggested to overcome the serious shortage of organs , xenografts have considerable attention in the last decade. Genetically modified pigs have been widely considered the most likely xenograft donors for human beings,however,It is a challenge for the traditional immunosuppressants,for the follow-up a series of rejection: Acute humoral xenogra...学位：医学硕士院系专业：医学院_外科学学号：2452011115335