Study on Gene Cloning, Expression and Bioactivity of Innate Immune Factors (MIF and pglyrp2) in Two Species of Croakers

鱼类所生活的水环境中充斥着大量的病原菌，引起的疾病每年都给海水鱼类养殖带来了巨大的损失，本论文以大黄鱼(Pseudosciaenacrocea)抗病遗传育种为研究背景，为了解哈维氏弧菌(Vibrioharveyi)感染大黄鱼过程中涉及的病原菌识别和炎症反应等免疫应答相关的分子机制，开展了两种石首鱼天然免疫因子的基因克隆、表达特性及生物学活性研究。 巨噬细胞移动抑制因子(Macrophagemigrationinhibitoryfactor，MIF)作为多功能的炎症细胞因子，在炎症疾病的发生发展过程中起着关键的调节作用，但是，关于鱼类MIF的功能研究和炎症致病机理的研究却报道甚少；肽聚糖受体是...Fishes are in intimate contact with a rich microbial flora and exposed to millions of potential pathogens daily, and commercial cultures have faced increasing and appreciable economic damage in recent years. This thesis was in this research context of large yellow croaker genetic breeding for resistance to pathogen vibrio, and studied on cloning, expression and bioactivity analysis of immune relat...学位：理学博士院系专业：海洋与环境学院海洋学系_海洋生物学学号：2242006015334