Study on the Biosynthetic Pathway of Polyketide MED and Cyclic Lipopeptide WAP-8294A2

在新药发现过程中，天然产物仍然是开发新药特别是发现新的药物先导化合物的最重要源泉。目前已从红树林植物内生真菌中分到大量结构新颖，且具有抗菌和（或者）抗肿瘤等活性的天然产物，包括生物碱、大环内酯、环肽、醌类、萜类、聚醚类、甾醇类、多糖类以及脂肪酸类等，为新药的筛选和研发提供了丰富的模式结构。 本篇论文第一篇介绍了红树内生真菌Phomopsissp.A123的去乙酰基真菌环氧二烯高产突变株A818的次级代谢产物分离和结构鉴定。经过细致的分离和详细的结构解析，从该突变株中分离得到21个真菌环氧二烯类化合物，其中包括含有-不饱和-&#6...Natural products are an important source for drug discovery, especially for new lead drugs. During this thesis study, we have isolated and identified a large number of new natural products with novel structures and biological activities. These natural products span a broad range of chemical structures, including alkaloids, macrocyclic lactones, cyclic peptides, quinones, terpenes, polyethers, ster...学位：理学博士院系专业：生命科学学院生物学系_微生物学学号：2172008015040