Identifying key developments, issues and questions relating to techniques of genome editing with engineered nucleases.

This paper discusses scientific, ethical and governance aspects of genome editing with engineered nucleases. First, the scientific state of the art for three major genome editing techniques and their current applications in humans, animals and plants are discussed. Ethical concepts and issues arising from these technologies are then identified. The next section raises considerations pertaining to governance of genome editing. Finally, questions for the Council to consider are raised