The rapid deterioration of the world’s major ecosystems has intensified the need for effective monitoring and development of operational indicators of ecosystem health, and the extension of health to describe regional ecosystems is a response to accumulating evidence that human-dominated ecosystems have become highly dysfunctional. The Lagoon of Venice is probably one of the world’s best-known examples of an ecosystem that has been historically influenced by human intervention since the XVth century. The area has a long history of industrial activity (even recent, mainly after World War II), with oil refining and several chemical production plants around the Lagoon. Only recently has Venice also been re...