Na jadre substituovane funkcni derivaty kyseliny pyrazin-2-karboxylove jako potencialni chemoterapeutika.

The synthesis of 5-alkyl-6-alkylsulfanyl- resp. 5-alkyl-6-arylsulfanylpyrazine-2-carboxamides and corresponding thioamides and hydrazides is reported in the submitted dissertation thesis. All the prepared compounds were tested for their antimycobacterial and antifungal activity. Compounds showed relatively low activity against M. tuberculosis H37Rv, in comparison with standard (rifampicin). The most potent of them were compounds with thioamide moiety at the position 2 of pyrazine ring. Antifungal activity of the prepared compounds was rather low. The highest activity showed compounds with amide moiety at the position 2 of pyrazine ring. Some of the synthesized compounds were also bioassayed as photosynthesis inhibitors by measuring the oxygen consumption in suspensions of chloroplasts. None of them, however, showed any activity.Available from STL Prague, CZ / NTK - National Technical LibrarySIGLECZCzech Republi