MACROMOLECULAR BASES OF DIRECTED HEMOGLOBIN MODIFICATION FOR CREATION OF ARTIFICIAL OXYGEN CARRIER

The investigation object is the oxygen carrier on base of the chemically-derivative hemoglobin. The aim is to create the functionally-full-bodied universal oxygen carrier being optimum by a molecular-mass composition and free from the limitations inherent in the donor blood on base of the chemical derivative hemoglobin by a directed modification method. A possibility to perform the directed hemoglobin modification for making the compounds with beforehand given fractional composition has been shown firstly. The intercommunication between macromolecular structure of the hemoglobin derivatives and their functioning as an artificial oxygen carrier has been determined. The chemical oxygen compound being optimum by the composition and functional charateristics has been made, its medicinal efficiency at introduction in dose of 4 g/kg on the models of the acute and fatal hemorrhage has been shown. 9 author's certificates for the inventions for procedures of making the chemical derivative hemoglobins of different fractional compositions have been obtained. The base of the medicinal artificial hemoglobin form with use of the chemical derivative hemoglobin has been created. Application field: blood service enterprises manufacturing blood substitutes of directed actionAvailable from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio