THE ROLE OF D2 AND D3 RECEPTORS OF DOPAMINE IN PRESYNAPTIC REGULATION OF THE CENTRAL DOPAMINERGIC NEUROTRANSMISSION

The work has been made on he-rats of the Wistar line. The method of the intrabrain microdialysis has been used on the free-movable animals and high effective liquid chromatography with electrochemical detection for the determination of dopamine and its metabolites. It has been shown, that the differences in the action mechanism of the typical and atypical neuroleptics are connected with its different affinity to D2 and D3 receptors of dopamine. Formulated and experimentally justified has been the hypothesis, according to which D3 receptors of dopamine predominantly have been engaged in the presynaptic regulation of the process of the dopamine release, while D2 receptors of dopamine control the biosynthesis process of dopamines in the basal ganglia of the rat's brain. It has been established, that the process of release and its autoreceptor regulation are more sensitive to the action of agonist D3 receptors of dopamine in the mesolymbic system as compared with the negrostriateed one. All work results are new, they can be used in studying the processes of regulation of synaptic transmission, search for the new antipsychotic substances with the atypic profile of actionAvailable from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio