SYNTHESIS AND PROPERTIES OF ARYL (HETERYL) ADAMANTYL KETONES

The influence of the substituent character in the adamantane skeleton on the correlation of the acylation-alkylation products has been specified; a possibility to create the aryl(heteryl)adamantyl ketones has been determined. The chemical synthesized compounds on the carbonyl group, adamantane and heterocyclic rings have been studied. The synthesis methods of the functional adamantane derivatives have been developed. The adamantyl-containing ketones and their derivatives (58 compounds) have been synthesized firstly. The interaction of chloranhydrides in the halogen-substituted adamantanecarbonic acids with Lewis catalyst has been investigated. The synthesis procedure of the difficult-accessible mixed dihalogen-substituents of the adamantane has been found. For a number of the synthesized compounds the strong cytostatic activity has been revealed, and also the favourable indications for the functional-important phosphorolipids have been specified.Available from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio