BIOPHYSICAL CRITERIA OF DEVELOPING POPULATION OF MICROORGANISMS AND THEIR ASSOCIATIONS IN CONTROLLED CONDITIONS

The investigation is based on studying dependences of the kinetic growth parameters of the microbic populations upon the environment factors in two types of the continuous cultivation - in the hemostasis and turbidostasis (pH-stasis), possibility on the performance and stability of the stationary changes, changeability of the signs of the microorganisms determinated by the chromosomic and plasmid genes. The bistable stationary states with height and low population density at substrate inhibition of the yeast growth by a phenol have been forecasted theoretically and confirmed in experiments. The population growth rate stimulation effect of the yeast by the low concentrations of the phenol inhibitors has been discovered. The positive population growth cooperativity effect of the bacteria at descrease of the population density has been discovered. The "experimental evolution machines" - experimental-theoretical models for study of the general microevolution regularities have been developed. It has been determined that the growing of the energetical substrate flow used by a population is the general criterion for microevolution of the microorganism populations. It is expedient to use the work results for intensification of the microbiological production processes on the toxic substrates (ethanol, methanol a.o.), in the biotechnology for increasing stability of the recombinant strain-producers, in the ecology and environment protection for forecasting introduction results of the genic-engineering strains of the microorganisms into the natural ecological systems.Available from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio