HORMONAL REGULATION OF REPRODUCTIVE FUNCTION AT ACTION OF UNFAVOURABLE ENVIRONMENT FACTORS

A number of the principial differences in the neurohormonal regulation of the gonadoliberin and gonadotropin secretion among females and males has been determined firstly. The presence of the zircadianic gonadoliberin rhythm in the vascular organ of the end plate among females and its absence among males have been shown. The presence of the secretion inhibitor of luteinizing hormone in the mediobasal hypothalamus by a hypophysis among males and its absence among females has been determined. The conceptions about physiological role of the vascular organ of end plate in the regulation of gonadoliberin secretion have been broadened sufficiently. The wide spreading of the peptidases damaging the gonadoliberin in the hypothalamus and increase of their activity under influence of the estradiol have been ahown firstly that reveals one of the mechanism of inverse feedback between estradiol level and secretion of the gonadotropions. It has been shown that among rats the almost whole progesterone is formed in the adrenal glands but the gonads make the sufficiently lesser contribution into its level. The wrong way, the most active sexual hormons - estradiol and testosterone are synthesized almost completely in the gonads. It has been determined firstly that among female rats the increase of the uterus mass is provided with the all the spectrum of the anabolic steroids - estrogens and androgens. The influence of 9 different chemical substances and electromagnetic fields on the hormonal regulation of the reproductive function has been studied. It has been determined that the majority of the different chemical nature xenobiotics possesses the primary neurotoxic effect. The direct gonadotoxic effect is found more rarely. Besides, the hepatotoxic effect influences on the reproduction regulation also. The theoretical importance of the investigation is concluded in the deepening of the representations about importance of the different reproduction regulation links and revealing the early breachs of the mutual relation between them under action of the unfavourable ecological factors.Available from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio