SYNTHESIS, STRUCTURE AND PROPERTIES OF 2,6-DI-SUBSTITUTED-4N-1,3-OXAZINE-4-ONES

The reaction of the acilyso(thyo)cyanates with substituted acetylenes leading to 1,3-oxazines has been investigated with enlisting of the quantum-chemical methods. The boundaries of applying the given reaction and also the influence of the original reagent structure as a synthesis method of 1,3-oxazines have been considered. The chemical properties of the synthesized compounds from a point of vision of making the different acyclic and heterocyclic systems have been studied. The synthesis methods of 4N-1,3-oxazine-4-ones and also the derivatives of pyramidine, triazole, oxadiazole, imidazole and esters of the malonamic acids have been developed. The small-toxic fungicides and antitumoral substances of a number of 1,3-oxazines have been made. The principial new procedures of making 1,3-oxazines used in the organic chemistry department of the St.-Petersburg Chemical-Pharmaceutical Institute in the purposive programmes on the synthesis of the new biologically-active compounds have been proposed. Application field: synthesis of nitrogen heterocycles, making of biologically active compoundsAvailable from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio