EFFECTS OF GLUCOCORTICOIDS IN EARLY ONTOGENESIS ON ACTIVITY OF TYROSINE HYDROXYLASE IN BRAIN OF RATS

On the rats of the line Vistar with use of the biochemical methods for determination of the tyrosine hydroxylase (TH) activity and content of the dofamine and norepinephrine, the ontogenesis of the catecholaminergical brain system after increasing level of the glucocorticoids during pregnancy has been investigated. The periods of the most active development of the mediator system have been determined. The ability of the glucocorticoids introduced to the pregnant female to activate TH in the brain of 20-day fetuses has been determined firstly. It has been proved that the enzyme activity depression in the brain of 21-day fetuses at introduction of the hormone on the 16-th and 18-th days of pregnancy is the arrest result of their general development. The manifestation of the opposite hormone effects is unequal among fetuses of the line Vistar, aggressive and tame Norway rats. The correlation of the genotype-dependent hormone actions on the general development and TH activity in the early ontogenesis determines the character of changing catecholaminergical brain system of the adult animalsAvailable from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio