We are concerned with the asymptotic theory of semiparametric estimation equations. We are dealing with estimation equations which have a parametric component of interest and a functional (nonparametric) nuisance component. We give sufficient conditions for the existence and the asymptotic normality of a consistent estimation equation estimator for the parameter of interest. These conditions concern the asymptotic distribution of the estimation function and of its derivative as well as the effect of the functional nuisance part in the estimation equation. In order to treat the nonparametric component we introduce a general differential calculus and a general mean value theorem. For the nonparametric part in the estimation equation we distin...