Radiobiological aspects of therapy planning for heavy charged particle beams

In order to achieve reliable RBE values for treatment planning, it is necessary to use a model, which is able to reproduce the experimental results of survival measurements. As as first step, a model has been developed, which predicts heavy ion inactivation probabilities depending on the X-ray sensitivity, the particle track structure and the morphological properties of the cell nucleus. Recently, the model has been extended for the calculation of survival after irradiation using spread out Bragg peaks, where only primary particles have been taken into account. In near future, there will be a further extension in order to include also the effects of fragmentation products. The main features of the model calculations will be summarized. (orig.)SIGLEAvailable from TIB Hannover: RO 801(93-51) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman