Add to ORKG"1"3C nmr spectroscopy has been applied to study the carbon flux distribution through parallel metabolism pathways in Corynebacterium glutamicum: diaminopimelate-dehydrogenase/succinylase (I), pentose phosphate way/glycolysis (II) and the flux through the tricarbon acid cycle (TCA cycle). The contribution of pathway I to the lysine production is a function of the ammonium ion concentration in the nutrient solution. Using 1-"1"3C and 6-"1"3C labeled glucose as substrates, it is demonstrated that the flux via way II correlates with the supply of NADPH generated by pathway II. TCA cycle suppression under glutamate production conditions is due to an enhanced flux of #alpha#-ketoglutarate to glutamate. In vivo nmr i...
Corynebacterium glutamicum is an important organism for the industrial production of amino acids suc...
The intracellular concentrations of the valine and leucine pathway intermediates in a Coryne-bacteri...
Corynebacterium glutamicum serves as important production host for small molecular compounds that ar...
Using our recently developed sensor reactor approach, lysine-producing, nongrowing Corynebacterium g...
The Gram-positive bacterium Corynebacterium glutamicum is used for the industrial production of amin...
Corynebacterium glutamicum is intensively used for the industrial large-scale (fed-) batch productio...
Growth of Corynebacterium glutamicum on mixtures of the carbon sources glucose and acetate is shown ...
Abstract Background Corynebacterium glutamicum has several anaplerotic pathways (anaplerosis), which...
In this study we applied elementary mode analysis and metabolic flux analysis to L-glutamate biosynt...
Growth of Corynebacterium glutamicum on mixtures of the carbon sources glucose and acetate is shown ...
The C3-C4 metabolite interconversion at the anaple-rotic node in many microorganisms involves a comp...
Wendisch VF, De Graaf AA, Sahm H, Eikmanns BJ. Quantitative determination of metabolic fluxes during...
International audienceThe effect of the presence of ammonia on [1-C-13]glucose metabolism in the rum...
Central carbon metabolism is the main source of energy required by organisms and it provides prec...
Metabolites are small molecular compounds that are found in various stages of the metabolic processe...
Corynebacterium glutamicum is an important organism for the industrial production of amino acids suc...
The intracellular concentrations of the valine and leucine pathway intermediates in a Coryne-bacteri...
Corynebacterium glutamicum serves as important production host for small molecular compounds that ar...
Using our recently developed sensor reactor approach, lysine-producing, nongrowing Corynebacterium g...
The Gram-positive bacterium Corynebacterium glutamicum is used for the industrial production of amin...
Corynebacterium glutamicum is intensively used for the industrial large-scale (fed-) batch productio...
Growth of Corynebacterium glutamicum on mixtures of the carbon sources glucose and acetate is shown ...
Abstract Background Corynebacterium glutamicum has several anaplerotic pathways (anaplerosis), which...
In this study we applied elementary mode analysis and metabolic flux analysis to L-glutamate biosynt...
Growth of Corynebacterium glutamicum on mixtures of the carbon sources glucose and acetate is shown ...
The C3-C4 metabolite interconversion at the anaple-rotic node in many microorganisms involves a comp...
Wendisch VF, De Graaf AA, Sahm H, Eikmanns BJ. Quantitative determination of metabolic fluxes during...
International audienceThe effect of the presence of ammonia on [1-C-13]glucose metabolism in the rum...
Central carbon metabolism is the main source of energy required by organisms and it provides prec...
Metabolites are small molecular compounds that are found in various stages of the metabolic processe...
Corynebacterium glutamicum is an important organism for the industrial production of amino acids suc...
The intracellular concentrations of the valine and leucine pathway intermediates in a Coryne-bacteri...
Corynebacterium glutamicum serves as important production host for small molecular compounds that ar...