Radiation fields, dosimetry, biokinetics and biophysical models for cancer induction by ionising radiation 1996-1999 Biokinetics and dosimetry of incorporated radionuclides. Final report

The final report 'Biokinetics and Dosimetry of Incorporated Radionuclides' presented here is one part of the 5 individual reports. The work to be carried out within this project is structured into four Work Packages: Workpackage 1 concentrates on ingested radionuclides, considering doses to the GI tract and radionuclide absorption. A major objective is the development of a new dosimetric model of the GI tract, taking account of most recent data on gut transit and dose to sensitive cells. Workpackage 2 seeks to improve and extend biokinetic and dosimetric models for systemic radionuclides. Existing models for adults and children will be extended to other elements and new models will be developed for the embryo and fetus. Workpackage 3 is to improve assessment of localised distribution of dose within tissues at the cellular level for specific examples of Auger emitters and alpha emitting isotopes, in relation to observed effects. The work will include experimental studies of dose/effect relationship and the development of localisation methods. Workpackage 4 concerns the development of computer codes for the new dosimetric models, quality assurance of the models and the calculation of dose coefficients. Formal sensitivity analysis will be used to identify critical areas of model development and to investigate the effects of variability and incertainty in biokinetic parameters. (orig.)Available from TIB Hannover: RO 2674(01/00) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLECommission of the European Communities, Brussels (Belgium). Directorate General for Science, Research and Development (DG 12)DEGerman