Characterization of the antibody response to vaccination and or infection with porcine circovirus type 2 and identification and characterization of a decoy epitope in the capsid protein

  • Trible, Benjamin Ralph
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Abstract

Doctor of PhilosophyDepartment of Diagnostic Medicine and PathobiologyRaymond R. R. RowlandChapter 1: Porcine circovirus-associated disease (PCVAD) encompasses a group of complex, multi-factorial syndromes, which are dependent on infection with porcine circovirus type 2 (PCV2). Current strains of PCV2 circulating in the field are phylogenically classified into two groups, termed PCV2a and 2b. Outbreaks of severe PCVAD in North America in 2005 are linked with a shift in the predominant circulating genotype, from PCV2a to PCV2b. Therefore genotype specific differences in pathogenesis and antigenicity have been suggested. Overall, evidence suggests pathogenicity is a function of the specific PCV2 isolate, regardless of genotype. In addition...

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