Driving Pressure During General Anesthesia for Open Abdominal Surgery (DESIGNATION):study protocol of a randomized clinical trial
- Hol, Liselotte
- Nijbroek, Sunny G. L. H.
- Neto, Ary Serpa
- de Abreu, Marcelo Gama
- Pelosi, Paolo
- Hemmes, Sabrine N. T.
- Aarts, Leon P. H. J.
- Akkerman, Ronald D. L.
- Albersen, Juliette J. E.
- Aurilio, Caterina
- Battaglini, Denise
- de Boer, Hans D.
- Boom, Annemieke
- Boer, Christa
- Brouwer, Tammo
- Buhre, Wolfgang F. F. A.
- Bulte, Carolina S. E.
- Edward-Rutten, Gitara M.
- Godfried, Marc B.
- Helmerhorst, Hendrik J. F.
- Hofland, Jan
- Hoogenboom, Hester
- Ten Hoope, W.
- Houweling, Bernard M.
- Huhn, Ragnar
- Konijn, Wanda
- Koopman-van Gemert, Ankie W. M. M.
- De Korte-de Boer, Dianne J.
- Kortekaas, Minke C.
- Van Lier, Felix
- Preckel, Benedikt
- Rad, Mandana
- Sansone, Pasquale
- Stamkot, Andre
- Stolker, Robert Jan
- Thiel, Bram
- Ubben, Johannes F. H.
- Struys, Michel M. R. F.
- In 't Veld, Bastiaan A.
- Wrigge, Hermann
- Zeillemaker-Hoekstra, Miriam
- van der Zwan, Tim
- Zwijsen, Johannes H. M. J.
- Hollmann, Markus W.
- Schultz, Marcus J.
DOIAbstract
Background Intraoperative driving pressure (Delta P) is associated with development of postoperative pulmonary complications (PPC). When tidal volume (V-T) is kept constant, Delta P may change according to positive end-expiratory pressure (PEEP)-induced changes in lung aeration. Delta P may decrease if PEEP leads to a recruitment of collapsed lung tissue but will increase if PEEP mainly causes pulmonary overdistension. This study tests the hypothesis that individualized high PEEP, when compared to fixed low PEEP, protects against PPC in patients undergoing open abdominal surgery. Methods The "Driving prESsure durIng GeNeral AnesThesIa for Open abdomiNal surgery trial" (DESIGNATION) is an international, multicenter, two-group, double-blind r...
Add to ORKG