Relations structure-fonction et propriétés immunologiques de la protéine Tat du VIH-1

HIV-1 induces the apoptosis of CD4+ T cells through multiple pathways. One such is by the HIV-1 Tat protein, which is secreted by virally infected cells and taken up by uninfected cells. Tat is expressed very early in the virus life cycle and plays a critical role in the transcription of HIV. We show that Tat proteins from patients with rapid disease progresion have greater trans-activational and apoptotic activities than from patients with slower rates of progression. The glutamine rich region of Tat appears to be implicated in these activities. The critical role of Tat in immunodeficiency makes Tat a good candidate for a component in an HIV-1 vaccine. The study of the antibodies raised by Tat shows the importance of using a full length protein. Furthermore, macaques vaccinated with Tat Oyi and challenged with SHIV showedAIX-MARSEILLE2-BU Sci.Luminy (130552106) / SudocSudocFranceF