Etude bibliographique de l'hépatite chronique du Dobermann

The Doberman hepatitis was described for the first time by Johnson in 1982. It mainly concerns females and the animal average age is around four and a half years. At the beginning, the clinical signs may be mild or absent. When the symptoms appear, it comes with a liver failure shown by anorexia, weight loss, polydipsia, polyuria, gastrointestinal signs and ascites. Most of dogs are presented in advanced stage sometimes with hepatic encephalopathy signs. Laboratory findings show a hepatocellular insufficiency and impaired biliary excretion. The histologic findings are typical of CAH with copper accumulation and cholestasis. The diagnosis is obtained thanks to histopathologic features. The prognosis is often poor and the surviving time depend of the stage of the presentation. The treatment is based on corticosteroid drug and copper chelator with a low copper diet. Pathogenesis is poorly understood; an immune response must be implicated. The significance of the increased hepatic copper concentration has not been determined.TOULOUSE3-BU Santé-Centrale (315552105) / SudocTOULOUSE-EN Vétérinaire (315552301) / SudocSudocFranceF