Protocadherin-17 Expression and Function in Vertebrate Brain: A Literature Review

For this project, I will be doing a systematic review on protocadherin-17 function in vertebrate brain development and function in the last 10 years. Protocadherins are members of cadherin superfamily. Cadherins are calcium-dependent cell adhesion molecules that are implicated to play crucial roles in the information and maintenance of tissues and organs in vertebrate animals. This review will summarize major findings regarding protocadherin-17 expression and function in major model organisms such as zebrafish and mice, as well as results from human studies. It is hoped that this work will be a valuable source for background knowledge of protocadherin-17 function in vertebrate brain formation, and help future researchers in their investigation of cellular and molecular mechanisms underlying cadherin function in brain development. The major method of collecting information for writing this review is perform online database search, and the project is scheduled to be completed by April 2021