PD-L1 expression in immune cells is a favorable prognostic factor for nasopharyngeal carcinoma
- Şahinli, Hayriye
- Akyürek, Nalan
- Yılmaz, Mukaddes
- Kandemir, Olcay
- Ocak Duran, Ayşe
- Kulaçoğlu, Sezer
- Uçar, Gökhan
- Acar, Elif
- Özet, Ahmet
- Gümüş, Mahmut
- Çakmak Öksüzoğlu, Ömür Berna
- Yıldırım Özdemir, Nuriye
DOIAbstract
Background: Programmed death-ligand 1 (PD-L1) has been determined as a reliable prognostic factor for various malignancies. In this study, we aimed to determine the prognostic effect of PD-L1 expression in tumor-infiltrating immune cells (TIICs) of nasopharyngeal carcinoma (NPC) patients.Methods: Seventy patients diagnosed with non-metastatic NPC were included in the study. PD-L1 expression on immune cells was analyzed by immunohistochemical method. Patients were categorized into two groups according to the PD-L1 expression level in TIICs (level of PD-L1 staining ≥5% positive vs <5% negative).Results: Median follow-up period was 34 months (range = 1 - 188). 1 and 2 years survival rate were found as 75% and 63% in PD-L1 negative TIICs group ...
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