Preparation and exploitation of tailored polymer resins for use in dynamic combinatial library synthesis

The thermodynamically controlled synthesis, amplification and isolation of macrocydic receptors from dynamic combinatorial libraries (DCLs) has been achieved in a single step using polymer-supported templates. By combining synthesis and affinity chromatography into one single step tedious separations via chromatographic techniques can be avoided, which opens new preparative possibilities especially in more complex libraries comprising an increased number of building blocks.EThOS - Electronic Theses Online ServiceGBUnited Kingdo