RNA Uridylation as a Novel Mechanism of Gene Regulation

Polyadenylation of mRNA 3' ends is a key event in gene expression, as the poly(A) tail both stabilizes the transcript and allows its translation. Until recently, only adenyl residues were known to be added to these 3' ends. However, when characterization of Schizosaccharomyces pombe Cid1 was undertaken. It was observed that the major activity of this enzyme was uridylating RNA.EThOS - Electronic Theses Online ServiceGBUnited Kingdo