Molecular mechanisms of the gut immune systems and effects on nutrient sensing cells

The nematode Trichinella spiralis produces a well characterised transient inflammation in the small intestine which is associated with hypophagia and weight loss. This correlates with an increase in cholecystokinin (CCK) secreting enteroendocrine cells (EEC) and is under the control of CD4+ T-cells. A later secondary bout of hypophagia corresponds with the T. spiralis larvae encysting in the striated muscle, which is independent of EEC, but thought to involve inflammatory cytokines. However the mechanisms governing both these responses remain unknown.EThOS - Electronic Theses Online ServiceGBUnited Kingdo