Add to ORKGA new asymmetric synthetic route to (-)-galanthamine (1.01), a potent Amaryllidaceae alkaloid used in the symptomatic treatment of early on-set Alztheimer's disease (AD), was successfully developed with complete stereocontrol. Key to achieving high chemo-and stereo-selectivity in this approach was the use of transition metal (IM) mediated reactions, in the form of an enyne RCM; a Heck coupling and a titanium based asymmetric allylation. Additionally, application of an asymmetric imino-aldol reaction resulted in the short total synthesis of two Lupin-type alkaloids, tashiromine (3.01) and epilupinine (3.02).EThOS - Electronic Theses Online ServiceGBUnited Kingdo
An imino-aldol reaction between phenyl chlorovalerate and a variety of (S)-tert butylsulfinimines wa...
The Annonaceous acetogenin cis-sylvaticin (3.12) displays potent antitumour activity. Using permanga...
A new strategy for the stereoselective synthesis of alkaloids with perhydro-9b-azaphenalene skeleton...
A new asymmetric synthetic route to (-)-galanthamine (1.01), a potent Amaryllidaceae alkaloid used i...
An asymmetric synthetic route to (−)-galanthamine (1), a pharmacologically active Amaryllidaceae alk...
A highly anti-selective formal imino-aldol methodology has been developed and applied to asymmetric ...
Synthetic routes towards the total synthesis of (?)-sparteine (1.1) have been investigated. An imino...
The first stereoselective total synthesis of the tetracyclic lupin alkaloid (+)-ß-isosparteine (+)-1...
An enantioselective synthesis of (-)-galanthamine has been realized in 11 linear steps starting from...
textDespite the enormous amount of work devoted to the synthesis of the anticholinesterase Amarylli...
The first stereoselective total synthesis of the tetracyclic lupin alkaloid (+)-ß-isosparteine (+)-1...
The first stereocontrolled total synthesis of iminosugar 1,4-dideoxy-1,4-imino-D-iditol is described...
The tetracyclic alkaloid galanthamine is used clinically in a number of countries for the symptomati...
The isoquinoline alkaloids form a unique class of compounds, exhibiting biological properties almost...
A novel stereocontrolled approach has been developed for the syntheses of tashiromine and epitashiro...
An imino-aldol reaction between phenyl chlorovalerate and a variety of (S)-tert butylsulfinimines wa...
The Annonaceous acetogenin cis-sylvaticin (3.12) displays potent antitumour activity. Using permanga...
A new strategy for the stereoselective synthesis of alkaloids with perhydro-9b-azaphenalene skeleton...
A new asymmetric synthetic route to (-)-galanthamine (1.01), a potent Amaryllidaceae alkaloid used i...
An asymmetric synthetic route to (−)-galanthamine (1), a pharmacologically active Amaryllidaceae alk...
A highly anti-selective formal imino-aldol methodology has been developed and applied to asymmetric ...
Synthetic routes towards the total synthesis of (?)-sparteine (1.1) have been investigated. An imino...
The first stereoselective total synthesis of the tetracyclic lupin alkaloid (+)-ß-isosparteine (+)-1...
An enantioselective synthesis of (-)-galanthamine has been realized in 11 linear steps starting from...
textDespite the enormous amount of work devoted to the synthesis of the anticholinesterase Amarylli...
The first stereoselective total synthesis of the tetracyclic lupin alkaloid (+)-ß-isosparteine (+)-1...
The first stereocontrolled total synthesis of iminosugar 1,4-dideoxy-1,4-imino-D-iditol is described...
The tetracyclic alkaloid galanthamine is used clinically in a number of countries for the symptomati...
The isoquinoline alkaloids form a unique class of compounds, exhibiting biological properties almost...
A novel stereocontrolled approach has been developed for the syntheses of tashiromine and epitashiro...
An imino-aldol reaction between phenyl chlorovalerate and a variety of (S)-tert butylsulfinimines wa...
The Annonaceous acetogenin cis-sylvaticin (3.12) displays potent antitumour activity. Using permanga...
A new strategy for the stereoselective synthesis of alkaloids with perhydro-9b-azaphenalene skeleton...