DNA double strand breaks arise endogenously in the cell as a result of routine activities such as metabolism and also as a result of exposure to exogenous agents such as ionising radiation. Repair of DNA DSBs is coordinated by two major repair pathways in mammalian cells; non-homologous end joining and homologous recombination. Nonhomologous end joining is the dominant repair pathway during G1 and G2 phase of the mammalian cell cycle. The core non-homologous end joining factors Ku, DNA-PKcs, XLF, DNA Ligase IV and XRCC4 are essential for efficient and accurate rejoining of double strand breaks. In 2004, Riballo et al. discovered that the ATM protein kinase and the Artemis endonuclease were important for repair of a fraction of DNA double st...
Each day every cell of a living organism is constantly exposed to numerous DNA damages deriving both...
Loss of p53, a transcription factor activated by cellular stress, is a frequent event in cancer. The...
Repair of various types of DNA damages are critical for cell survival. Of these, DNA double-strand b...
Abstract To maintain genomic stability and ensure the fidelity of chromosomal transmission, cells re...
DNA double-strand break (DSB) signalling and repair is crucial to preserve genomic integrity and mai...
Double-strand breaks (DSBs) are toxic lesions that can be generated by exposure to genotoxic agents ...
DNA damage may result in various pathological conditions and contributes to aging and development of...
The protein p53 binding protein one (53BP1) was discovered in a yeast two-hybrid screen that used th...
Deoxyribonucleic acid double-strand breaks (DSBs) are cytotoxic lesions that must be repaired either...
53BP1 is a conserved nuclear protein that localizes rapidly at the sites of double strand breaks fol...
Upon DNA damage, p53-binding protein 1 (53BP1) relocalizes to sites of DNA double-strand breaks and ...
Repair of various types of DNA damages are critical for cell survival. Of these, DNA double-strand b...
<div><p>53BP1 regulates DNA double-strand break (DSB) repair. In functional assays for specific DSB ...
DNA damage is ubiquitous to all organisms and very complex pathways have evolved to recognize and re...
DNA double-strand breaks (DSBs) represent the most deleterious type of DNA damage as they pose a ser...
Each day every cell of a living organism is constantly exposed to numerous DNA damages deriving both...
Loss of p53, a transcription factor activated by cellular stress, is a frequent event in cancer. The...
Repair of various types of DNA damages are critical for cell survival. Of these, DNA double-strand b...
Abstract To maintain genomic stability and ensure the fidelity of chromosomal transmission, cells re...
DNA double-strand break (DSB) signalling and repair is crucial to preserve genomic integrity and mai...
Double-strand breaks (DSBs) are toxic lesions that can be generated by exposure to genotoxic agents ...
DNA damage may result in various pathological conditions and contributes to aging and development of...
The protein p53 binding protein one (53BP1) was discovered in a yeast two-hybrid screen that used th...
Deoxyribonucleic acid double-strand breaks (DSBs) are cytotoxic lesions that must be repaired either...
53BP1 is a conserved nuclear protein that localizes rapidly at the sites of double strand breaks fol...
Upon DNA damage, p53-binding protein 1 (53BP1) relocalizes to sites of DNA double-strand breaks and ...
Repair of various types of DNA damages are critical for cell survival. Of these, DNA double-strand b...
<div><p>53BP1 regulates DNA double-strand break (DSB) repair. In functional assays for specific DSB ...
DNA damage is ubiquitous to all organisms and very complex pathways have evolved to recognize and re...
DNA double-strand breaks (DSBs) represent the most deleterious type of DNA damage as they pose a ser...
Each day every cell of a living organism is constantly exposed to numerous DNA damages deriving both...
Loss of p53, a transcription factor activated by cellular stress, is a frequent event in cancer. The...
Repair of various types of DNA damages are critical for cell survival. Of these, DNA double-strand b...