An investigation into the cis-platin resistance exhibited by MMR-defective S. Cerevisiae cells

The primary function of the mismatch repair (MMR) pathway is to protect cells against the mutagenic and cytotoxic effects of mismatches incorporated by polymerases during replication. Accordingly, mutations in the MMR genes are commonly identified in patients with hereditary non-polyposis colon cancer (HNPCC) and somatic colorectal cancers. MMR function is of particular importance in cells exposed to DNA-damaging agents, as aberrant processing of damaged bases and erroneous bypass of bulky lesions increase the tendency for mismatch incorporation. The precise role of the MMR proteins in the processing of CDDP-induced DNA damage is, however, poorly understood.EThOS - Electronic Theses Online ServiceGBUnited Kingdo