Therapeutic targeting and clinical assessment of the tumour vasculature

The tumour vascular network is essential for tumour growth. Over the next few years, the use of vascular targeting drugs in the treatment of patients with cancer will escalate, which in turn will increase demand for non-invasive methods of assessing tumour vasculature. A perfusion CT technique was developed, allowing measurement of tumour vascular leakage (K) and blood volume (BV) of entire large tumours. This technique is shown to improve on measurement repeatability compared to conventional single level techniques, and can be used to measure tumour vascular changes following treatment.EThOS - Electronic Theses Online ServiceGBUnited Kingdo