Cryptolepine is a tetracyclic, aromatic natural product, isolated from West African shrubs of the Cryptolepis species, consisting of fused indole and quinoline rings. Due to its polyaromatic character it is able to intercalate into DNA showing a unique selectivity for non-alternating GC base pairs. Cryptolepine, and especially its halogenated analogues, have been investigated for their anti-malarial and anti-cancer activity, the latter being the area of interest of this thesis. A number of novel halogenated indoloquinoline cryptolepine analogues were synthesised in order to determine their abilities to interact with DNA, and to inhibit topoisomerase II activity. In vitro cytotoxicity testing was carried out using human tumor cell lines MCF-...
The prospect of eradicating malaria continues to be challenging in the face of increasing parasite r...
Cryptolepis sanguinolenta (Lindl.) Schltr (Periplocaceae), has a longstanding traditional use in the...
On the basis of the original lead neocryptolepine or 5-methyl-5H-indolo[2,3-b]quinoline, an alkaloid...
Cryptolepine is a tetracyclic, aromatic natural product, isolated from West African shrubs of the Cr...
This project investigated the development of novel anticancer agents with good efficacy and selecti...
A small library of cryptolepine analogues were synthesised incorporating halogens and/or nitrogen co...
noThe plant derived indoloquinoline alkaloid cryptolepine was investigated for its cytotoxic propert...
Cryptolepine hydrochloride is an indoloquinoline alkaloid isolated from the roots of Cryptolepis san...
Cryptolepine, neocryptolepine and isocryptolepine are naturally occurring indoloquinoline alkaloids ...
The indoloquinoline alkaloid cryptolepine 1 has potent in vitro antiplasmodial activity, but it is a...
NoThe indoloquinoline alkaloid cryptolepine 1 has potent in vitro antiplasmodial activity, but it is...
Cryptolepine and neocryptolepine are two indoloquinoline alkaloids isolated from the roots of the Af...
A series of cryptolepine derivatives has been synthesized through the incorporation of short basic s...
Neocryptolepine, which is a kind of tetracyclic indoloquinoline alkaloid, exhibits the inhibition of...
On the basis of the original lead neocryptolepine or 5-methyl-5H-indolo[2,3-b]quinoline, an alkaloid...
The prospect of eradicating malaria continues to be challenging in the face of increasing parasite r...
Cryptolepis sanguinolenta (Lindl.) Schltr (Periplocaceae), has a longstanding traditional use in the...
On the basis of the original lead neocryptolepine or 5-methyl-5H-indolo[2,3-b]quinoline, an alkaloid...
Cryptolepine is a tetracyclic, aromatic natural product, isolated from West African shrubs of the Cr...
This project investigated the development of novel anticancer agents with good efficacy and selecti...
A small library of cryptolepine analogues were synthesised incorporating halogens and/or nitrogen co...
noThe plant derived indoloquinoline alkaloid cryptolepine was investigated for its cytotoxic propert...
Cryptolepine hydrochloride is an indoloquinoline alkaloid isolated from the roots of Cryptolepis san...
Cryptolepine, neocryptolepine and isocryptolepine are naturally occurring indoloquinoline alkaloids ...
The indoloquinoline alkaloid cryptolepine 1 has potent in vitro antiplasmodial activity, but it is a...
NoThe indoloquinoline alkaloid cryptolepine 1 has potent in vitro antiplasmodial activity, but it is...
Cryptolepine and neocryptolepine are two indoloquinoline alkaloids isolated from the roots of the Af...
A series of cryptolepine derivatives has been synthesized through the incorporation of short basic s...
Neocryptolepine, which is a kind of tetracyclic indoloquinoline alkaloid, exhibits the inhibition of...
On the basis of the original lead neocryptolepine or 5-methyl-5H-indolo[2,3-b]quinoline, an alkaloid...
The prospect of eradicating malaria continues to be challenging in the face of increasing parasite r...
Cryptolepis sanguinolenta (Lindl.) Schltr (Periplocaceae), has a longstanding traditional use in the...
On the basis of the original lead neocryptolepine or 5-methyl-5H-indolo[2,3-b]quinoline, an alkaloid...