Molecular analysis of factors involved in regulation of protein expression by recombinant Chinese hamster ovary (CHO) cells

The demand for approved biopharmaceuticals products from animal cell culture have been rapidly increasing since last few decades. Many efforts have been made on process refining in the past, and now, works are focusing on the selection or generation of high producer cell lines. It was therefore very important to understanding the molecular mechanisms underlying the existing high producing cell lines and to identify cellular regulators responsible for enhanced productivity.EThOS - Electronic Theses Online ServiceGBUnited Kingdo