Intracellular signalling in eosinophils : differential roles for phosphoinositide 3-kinase and p38 MAP kinase in cellular responses to chemoattractants

Eosinophils are characteristic infiltrating cells in asthmatic airways and may contribute to allergic and inflammatory diseases pathology through the ability of their products to produce chronic inflammatory and remodelling processes. One focus of efforts to define new therapeutic targets for chronic inflammatory diseases has been the study of mechanisms through which eosinophils are recruited to tissues and become activated, leading to secretion of reactive oxygen species, inflammatory mediators, cationic proteins and cytokines. The signalling pathways responsible for evoking migratory and secretory response in human eosinophils are incompletely understood.EThOS - Electronic Theses Online ServiceGBUnited Kingdo