Novel palladium catalysed [3+2] cycloadditions towards functionalised aza-bicycles

Novel pyrrolidine, indolizidine and azepine ring systems have been prepared via the palladium catalysed [3+2] cycloaddition of cyclic imines with vinylcyclopropanes. The reaction of simple cyclic imines with various functionalised vinylcyclopropanes, provided a range of bicyclic systems, as potential scaffolds for further elaboration. The application of functionalised cyclic imines derived from enecarbamates was limited due to difficulties generating the imine bond. The developed methodology was also employed in the formation of pyrrolooxazinone products, as templates for functionalised proline syntheses.EThOS - Electronic Theses Online ServiceGBUnited Kingdo