Effect of aging and obesity on the expression of dyslipidemia in children from families with familial combined hyperlipidaemia

International audienceObjective: To delineate the mechanism(s) responsible for the increased secretion of very low density lipoprotein particles (VLDL) in patients with familial combined hyperlipidemia (FCH). Methods: In 194 young adults (1.5 mmol. l-1} and/or small dense LDL were observed only sporadically. After 5-year follow-up, BMI increased in both groups and this increase was associated with changes in apoB (r=0.27, p<0.05), TG (r=0.30, p<0.01), VLDL-c (r=0.22, p<0.05), VLDL-TG (r=0.25, p<0.05) and HDL-c (r= -0.27, p