Add to ORKGPrimary hepatocytes maintained in culture progressively down regulate liver-specific genes and lose their characteristic function and morphology. This process, termed dedifferentiation, is a hindrance to in vitro modelling of systems such as xenobiotic metabolism, liver disease and regeneration. However the results presented here demonstrate that dedifferentiated hapatocytes spontaneously induce expression of ductal genes, and therefore represent a useful model of cell reprogramming.EThOS - Electronic Theses Online ServiceGBUnited Kingdo
AuthorWe previously demonstrated that mature rat hepatocytes transdifferentiate to bile ductular cel...
The limited availability of hepatic tissue suitable for the treatment of liver disease and drug rese...
著者最終原稿 CC-BY-NC-NDMature hepatocytes are suggested to possess a capacity for bile ductular transdiff...
Direct reprogramming represents an easy technique to generate hepatocyte-like cells (iHeps) from som...
The liver is an essential organ that aids in metabolic processes, protein synthesis and detoxificati...
We have designed and implemented a novel and robust approach to obtain hepatocytes from individuals ...
Pluripotent stem cells (PSCs) are a potential renewable source of hepatocytes, which is needed for d...
SummaryThe liver is thought to utilize facultative stem cells, also known as “oval cells” or “atypic...
Liver regeneration is crucial for the maintenance of liver functional mass during homeostasis and di...
International audienceThe discovery of the wide plasticity of most cell types means that it is now p...
SummaryThe generation of large numbers of functional human hepatocytes for cell-based approaches to ...
SummaryRecent studies have demonstrated direct reprogramming of fibroblasts into a range of somatic ...
Hepatocytes are dynamic cells that, upon injury, can alternate between nondividing differentiated an...
The limited supply and expansion capacity of primary human hepatocytes presents major challenges for...
Liver regeneration is crucial for the maintenance of liver functional mass during homeostasis and di...
AuthorWe previously demonstrated that mature rat hepatocytes transdifferentiate to bile ductular cel...
The limited availability of hepatic tissue suitable for the treatment of liver disease and drug rese...
著者最終原稿 CC-BY-NC-NDMature hepatocytes are suggested to possess a capacity for bile ductular transdiff...
Direct reprogramming represents an easy technique to generate hepatocyte-like cells (iHeps) from som...
The liver is an essential organ that aids in metabolic processes, protein synthesis and detoxificati...
We have designed and implemented a novel and robust approach to obtain hepatocytes from individuals ...
Pluripotent stem cells (PSCs) are a potential renewable source of hepatocytes, which is needed for d...
SummaryThe liver is thought to utilize facultative stem cells, also known as “oval cells” or “atypic...
Liver regeneration is crucial for the maintenance of liver functional mass during homeostasis and di...
International audienceThe discovery of the wide plasticity of most cell types means that it is now p...
SummaryThe generation of large numbers of functional human hepatocytes for cell-based approaches to ...
SummaryRecent studies have demonstrated direct reprogramming of fibroblasts into a range of somatic ...
Hepatocytes are dynamic cells that, upon injury, can alternate between nondividing differentiated an...
The limited supply and expansion capacity of primary human hepatocytes presents major challenges for...
Liver regeneration is crucial for the maintenance of liver functional mass during homeostasis and di...
AuthorWe previously demonstrated that mature rat hepatocytes transdifferentiate to bile ductular cel...
The limited availability of hepatic tissue suitable for the treatment of liver disease and drug rese...
著者最終原稿 CC-BY-NC-NDMature hepatocytes are suggested to possess a capacity for bile ductular transdiff...