This thesis summarizes a research programme on the role of hypoxia-inducible factor (HIF) and its 2alpha subunit in systemic human physiology. Experiments were performed to assess the role of HIF in the regulation of skeletal muscle metabolism, cardiac anatomy, function and energy metabolism, and in cardiopulmonary physiology. Patients with different genetic mutations affecting the HIF pathway were recruited for each main study. Chapter 1 presents an overview of human physiological responses to hypoxia in a historical perspective, with particular attention to the areas of human physiology that are relevant for the studies presented in the experimental chapters. Chapter 1 also presents a summary of the HIF pathway and the novel findings pres...
Many diseases of the cardiovascular system involve an element of hypoxia due to impairments in oxyge...
What is the topic of this review? This review is principally concerned with results from studies of ...
Muscular dystrophies (MDs) are a group of inherited degenerative muscle disorders characterized by a...
This thesis summarizes a research programme on the role of hypoxia-inducible factor (HIF) and its 2a...
The research in this thesis investigated the role of the hypoxia-inducible factor (HIF) family of tr...
BACKGROUND: The von Hippel-Lindau tumour suppressor protein-hypoxia-inducible factor (VHL-HIF) pathw...
When humans are exposed to hypoxia, systemic and intracellular changes operate together to minimise ...
The von Hippel–Lindau tumour suppressor protein–hypoxia-inducible factor (VHL–HIF) pathway has attra...
The hypoxia-inducible factors (HIFs; isoforms HIF-1α, HIF-2α, HIF-3α) mediate many responses to hypo...
Intracellular responses to hypoxia are coordinated by the von Hippel-Lindau--hypoxia-inducible facto...
Molecular epidemiological studies conducted to date reveal a close relationship between the polymorp...
Introduction: Organisms are exposed to oxygen deprivation (Hypoxia) in various physiological and pat...
The hypoxia-inducible factor (HIF) family of transcription factors directs a coordinated cellular re...
Hypoxia-inducible factor (HIF) appears to function as a global master regulator of cellular and syst...
By undertaking a number of different experimental approaches at the genetic, cellular/ molecular and...
Many diseases of the cardiovascular system involve an element of hypoxia due to impairments in oxyge...
What is the topic of this review? This review is principally concerned with results from studies of ...
Muscular dystrophies (MDs) are a group of inherited degenerative muscle disorders characterized by a...
This thesis summarizes a research programme on the role of hypoxia-inducible factor (HIF) and its 2a...
The research in this thesis investigated the role of the hypoxia-inducible factor (HIF) family of tr...
BACKGROUND: The von Hippel-Lindau tumour suppressor protein-hypoxia-inducible factor (VHL-HIF) pathw...
When humans are exposed to hypoxia, systemic and intracellular changes operate together to minimise ...
The von Hippel–Lindau tumour suppressor protein–hypoxia-inducible factor (VHL–HIF) pathway has attra...
The hypoxia-inducible factors (HIFs; isoforms HIF-1α, HIF-2α, HIF-3α) mediate many responses to hypo...
Intracellular responses to hypoxia are coordinated by the von Hippel-Lindau--hypoxia-inducible facto...
Molecular epidemiological studies conducted to date reveal a close relationship between the polymorp...
Introduction: Organisms are exposed to oxygen deprivation (Hypoxia) in various physiological and pat...
The hypoxia-inducible factor (HIF) family of transcription factors directs a coordinated cellular re...
Hypoxia-inducible factor (HIF) appears to function as a global master regulator of cellular and syst...
By undertaking a number of different experimental approaches at the genetic, cellular/ molecular and...
Many diseases of the cardiovascular system involve an element of hypoxia due to impairments in oxyge...
What is the topic of this review? This review is principally concerned with results from studies of ...
Muscular dystrophies (MDs) are a group of inherited degenerative muscle disorders characterized by a...