Add to ORKGSite-selective protein modification has become an important tool to study protein functions in chemical biology. In the preliminary work, allyl sulfides were found to be reactive substrates in aqueous cross-metathesis (CM) enabling the first examples of protein modification via this approach. In order to access the enhanced CM reactivity of allyl sulfide on proteins, facile chemical methods to install S-allyl cysteine on protein surface were developed. In particular, a cysteine-specific allylating reagent – allyl selenocyanate was used on protein substrate for the first time. The substrate scope of allyl sulfide-tagged proteins and factors that affect the outcome of CM was also investigated. A range of metathesis substrates containing diffe...
Olefin cross-metathesis (CM) is a viable reaction for the modification of alkene-containing proteins...
Chemical modification of proteins is critical for many areas of biochemistry and medicine. Several m...
For a reaction to be generally useful for protein modification, it must be site-selective and effici...
Site-selective protein modification has become an important tool to study protein functions in chemi...
Allyl sulfides undergo efficient cross-metathesis in aqueous media with Hoveyda-Grubbs second genera...
Allyl sulfides undergo efficient cross-metathesis in aqueous media with Hoveyda-Grubbs second genera...
Allyl sulfides undergo efficient cross-metathesis in aqueous media with Hoveyda-Grubbs second genera...
Olefin metathesis has recently emerged as a viable reaction for chemical protein modification. The s...
Cross-metathesis (CM) has recently emerged as a viable strategy for protein modification. Here, effi...
Olefin metathesis has become a mainstay in organic synthesis.1 Cross-metathesis (CM), however, is la...
Cross-metathesis (CM) has recently emerged as a viable strategy for protein modification. Here, effi...
Multiple, complementary methods are reported for the chemical conversion of cysteine to S-allyl cyst...
Olefin metathesis has emerged as a powerful tool in organic synthesis. The activating effect of an a...
Olefin metathesis has emerged as a powerful tool in organic synthesis. The activating effect of an a...
Olefin cross-metathesis (CM) is a viable reaction for the modification of alkene-containing proteins...
Olefin cross-metathesis (CM) is a viable reaction for the modification of alkene-containing proteins...
Chemical modification of proteins is critical for many areas of biochemistry and medicine. Several m...
For a reaction to be generally useful for protein modification, it must be site-selective and effici...
Site-selective protein modification has become an important tool to study protein functions in chemi...
Allyl sulfides undergo efficient cross-metathesis in aqueous media with Hoveyda-Grubbs second genera...
Allyl sulfides undergo efficient cross-metathesis in aqueous media with Hoveyda-Grubbs second genera...
Allyl sulfides undergo efficient cross-metathesis in aqueous media with Hoveyda-Grubbs second genera...
Olefin metathesis has recently emerged as a viable reaction for chemical protein modification. The s...
Cross-metathesis (CM) has recently emerged as a viable strategy for protein modification. Here, effi...
Olefin metathesis has become a mainstay in organic synthesis.1 Cross-metathesis (CM), however, is la...
Cross-metathesis (CM) has recently emerged as a viable strategy for protein modification. Here, effi...
Multiple, complementary methods are reported for the chemical conversion of cysteine to S-allyl cyst...
Olefin metathesis has emerged as a powerful tool in organic synthesis. The activating effect of an a...
Olefin metathesis has emerged as a powerful tool in organic synthesis. The activating effect of an a...
Olefin cross-metathesis (CM) is a viable reaction for the modification of alkene-containing proteins...
Olefin cross-metathesis (CM) is a viable reaction for the modification of alkene-containing proteins...
Chemical modification of proteins is critical for many areas of biochemistry and medicine. Several m...
For a reaction to be generally useful for protein modification, it must be site-selective and effici...