International audienceThe main cause of Rett syndrome (RTT), a pervasive development disorder almost exclusively affecting females, is a mutation in the methyl-CpG binding protein 2 (MeCP2) gene. To date, no cure for RTT exists, although disease reversibility has been demonstrated in animal models. Emerging evidence from our and other laboratories indicates a potential role of oxidative stress (OS) in RTT. This review examines the current state of the knowledge on the role of OS in explaining the natural history, genotype-phenotype correlation, and clinical heterogeneity of the human disease. Biochemical evidence of OS appears to be related to neurological symptom severity, mutation type, and clinical presentation. These findings pave the w...
Rett syndrome is a rare neurodevelopmental disorder affecting almost exclusively females associated ...
Copyright © 2014 Cinzia Signorini et al.This is an open access article distributed under theCreative...
Objectives: Rett syndrome (RTT) is an X-linked autism spectrum disorder caused by mutations in the M...
The main cause of Rett syndrome (RTT), a pervasive development disorder almost exclusively affecting...
The oxidative stress (OS) hypothesis is able to explain several features of Rett syndrome (RTT), a p...
Rett syndrome (RTT, MIM 312750) is a rare and orphan progressive neurodevelopmental disorder affecti...
Rett syndrome (RS). a progressive severe neurodevelopmental disorder mainly caused by de novo mutati...
Rett syndrome (RTT) is an orphan progressive neurodevelopmental disease affecting almost exclusively...
As MeCP2 acts a multifunctional regulator of gene transcription, knowing the gene mutation is suffic...
Rett syndrome (RTT) is a rare neurodevelopmental disorder affecting almost exclusively females, caus...
AbstractRett syndrome (RTT) is a rare neurodevelopmental disorder affecting almost exclusively femal...
Rett syndrome (RTT) is a rare neurodevelopmental disorder affecting almost exclusively females, caus...
<p><i>Objectives</i>: Oxidative stress seems to be involved in Rett syndrome (RTT). The aim of this ...
Objectives: Oxidative stress seems to be involved in Rett syndrome (RTT). The aim of this study was ...
Rett syndrome (RTT) and MECP2 duplication syndrome (MDS) are neurodevelopmental disorders caused by ...
Rett syndrome is a rare neurodevelopmental disorder affecting almost exclusively females associated ...
Copyright © 2014 Cinzia Signorini et al.This is an open access article distributed under theCreative...
Objectives: Rett syndrome (RTT) is an X-linked autism spectrum disorder caused by mutations in the M...
The main cause of Rett syndrome (RTT), a pervasive development disorder almost exclusively affecting...
The oxidative stress (OS) hypothesis is able to explain several features of Rett syndrome (RTT), a p...
Rett syndrome (RTT, MIM 312750) is a rare and orphan progressive neurodevelopmental disorder affecti...
Rett syndrome (RS). a progressive severe neurodevelopmental disorder mainly caused by de novo mutati...
Rett syndrome (RTT) is an orphan progressive neurodevelopmental disease affecting almost exclusively...
As MeCP2 acts a multifunctional regulator of gene transcription, knowing the gene mutation is suffic...
Rett syndrome (RTT) is a rare neurodevelopmental disorder affecting almost exclusively females, caus...
AbstractRett syndrome (RTT) is a rare neurodevelopmental disorder affecting almost exclusively femal...
Rett syndrome (RTT) is a rare neurodevelopmental disorder affecting almost exclusively females, caus...
<p><i>Objectives</i>: Oxidative stress seems to be involved in Rett syndrome (RTT). The aim of this ...
Objectives: Oxidative stress seems to be involved in Rett syndrome (RTT). The aim of this study was ...
Rett syndrome (RTT) and MECP2 duplication syndrome (MDS) are neurodevelopmental disorders caused by ...
Rett syndrome is a rare neurodevelopmental disorder affecting almost exclusively females associated ...
Copyright © 2014 Cinzia Signorini et al.This is an open access article distributed under theCreative...
Objectives: Rett syndrome (RTT) is an X-linked autism spectrum disorder caused by mutations in the M...