In order to investigate further the mode of action of these compounds, synthesis of proteomic probes was attempted. Synthetic design and attempts are presented chapter VII. To establish whether there was 24-SMT present in the blood stream form of T. b. brucei, a Northern blot was carried out. This confirmed transcription of the enzyme which was then cloned, over expressed and purified (Chapter VIII). Enzyme assays were carried out against the recombinant enzyme.EThOS - Electronic Theses Online ServiceGBUnited Kingdo
This paper describes the synthesis of some novel azasterols based on (20R,22xi)-5alpha-pregnan-20-(p...
Ergosterol biosynthesis and homeostasis in the parasitic protozoan Trypanosoma brucei was analyzed b...
Trypanosoma brucei, the causative agent for human African trypanosomiasis, is an emerging ergosterol...
In order to investigate further the mode of action of these compounds, synthesis of proteomic probes...
A series of azasterol derivatives, designed as potential inhibitors of the Delta(24)-sterol methyltr...
A series of azasterol derivatives, designed as potential inhibitors of the Delta(24)-sterol methyltr...
A series of azasterol derivatives, designed as potential inhibitors of the Delta(24)-sterol methyltr...
There is an urgent need for new drugs to treat leishmaniasis and Chagas disease. One important drug ...
There is an urgent need for new drugs to treat leishmaniasis and Chagas disease. One important drug ...
There is an urgent need for new drugs to treat leishmaniasis and Chagas disease. One important drug ...
There is an urgent need for new drugs to treat leishmaniasis and Chagas disease. One important drug ...
Sterol 14α-demethylase (SDM) is essential for sterol biosynthesis and is the primary molecular...
Current treatments for diseases caused by apicomplexan and trypanosomatid parasites are inadequate d...
Current treatments for diseases caused by apicomplexan and trypanosomatid parasites are inadequate d...
This paper describes the synthesis of some novel azasterols based on (20R,22xi)-5alpha-pregnan-20-(p...
This paper describes the synthesis of some novel azasterols based on (20R,22xi)-5alpha-pregnan-20-(p...
Ergosterol biosynthesis and homeostasis in the parasitic protozoan Trypanosoma brucei was analyzed b...
Trypanosoma brucei, the causative agent for human African trypanosomiasis, is an emerging ergosterol...
In order to investigate further the mode of action of these compounds, synthesis of proteomic probes...
A series of azasterol derivatives, designed as potential inhibitors of the Delta(24)-sterol methyltr...
A series of azasterol derivatives, designed as potential inhibitors of the Delta(24)-sterol methyltr...
A series of azasterol derivatives, designed as potential inhibitors of the Delta(24)-sterol methyltr...
There is an urgent need for new drugs to treat leishmaniasis and Chagas disease. One important drug ...
There is an urgent need for new drugs to treat leishmaniasis and Chagas disease. One important drug ...
There is an urgent need for new drugs to treat leishmaniasis and Chagas disease. One important drug ...
There is an urgent need for new drugs to treat leishmaniasis and Chagas disease. One important drug ...
Sterol 14α-demethylase (SDM) is essential for sterol biosynthesis and is the primary molecular...
Current treatments for diseases caused by apicomplexan and trypanosomatid parasites are inadequate d...
Current treatments for diseases caused by apicomplexan and trypanosomatid parasites are inadequate d...
This paper describes the synthesis of some novel azasterols based on (20R,22xi)-5alpha-pregnan-20-(p...
This paper describes the synthesis of some novel azasterols based on (20R,22xi)-5alpha-pregnan-20-(p...
Ergosterol biosynthesis and homeostasis in the parasitic protozoan Trypanosoma brucei was analyzed b...
Trypanosoma brucei, the causative agent for human African trypanosomiasis, is an emerging ergosterol...
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