To obtain a complete understanding of the behaviour of proteins it is necessary to characterise all accessible conformations. This includes not only folded structures, but also the partially and fully unfolded states populated during folding and mis-folding. The existence of intrinsically disordered proteins (IDPs) adds a further category. The heterogeneous range of structures comprising disordered states (DS) presents a challenge for structure determination, making an ensemble description essential. Recent advances in techniques such as nuclear magnetic resonance (NMR) spectroscopy allow site-specific structural information to be obtained for DS. This thesis focuses on the development of computational methods for characterising DS of prote...
International audienceIntrinsically disordered proteins (IDPs) or intrinsically disordered regions (...
Intrinsically disordered proteins (IDP) are abundant in the human genome and have recently emerged a...
In the post genomic era, as more and more genome sequences are becoming known and hectic efforts are...
For a long time, it has been thought that a specific and well-defined three-dimensional (3D) structu...
International audienceIntrinsically disordered proteins (IDPs) perform their function despite their ...
International audienceThere is growing interest in the development of physical methods to study the ...
Disordered states of proteins include the biologically functional intrinsically disordered proteins ...
International audienceIn this review, we detail the most common experimental approaches to assess an...
The study of intrinsically disordered proteins has rapidly advanced since the identification of the ...
Disordered proteins are one class of proteins which do not possess well-folded three-dimensional str...
Recent advances in NMR methodology and techniques allow the structural investigation of biomolecules...
International audienceThe concept of intrinsically disordered proteins (IDPs) has emerged relatively...
Près de 40% des protéines présentes dans les cellules sont prédites partiellement ou complètement dé...
AbstractThe determination of conformational preferences in unfolded and disordered proteins is an im...
Intrinsically disordered proteins (IDP) are abundant in the human genome and have recently emerged a...
International audienceIntrinsically disordered proteins (IDPs) or intrinsically disordered regions (...
Intrinsically disordered proteins (IDP) are abundant in the human genome and have recently emerged a...
In the post genomic era, as more and more genome sequences are becoming known and hectic efforts are...
For a long time, it has been thought that a specific and well-defined three-dimensional (3D) structu...
International audienceIntrinsically disordered proteins (IDPs) perform their function despite their ...
International audienceThere is growing interest in the development of physical methods to study the ...
Disordered states of proteins include the biologically functional intrinsically disordered proteins ...
International audienceIn this review, we detail the most common experimental approaches to assess an...
The study of intrinsically disordered proteins has rapidly advanced since the identification of the ...
Disordered proteins are one class of proteins which do not possess well-folded three-dimensional str...
Recent advances in NMR methodology and techniques allow the structural investigation of biomolecules...
International audienceThe concept of intrinsically disordered proteins (IDPs) has emerged relatively...
Près de 40% des protéines présentes dans les cellules sont prédites partiellement ou complètement dé...
AbstractThe determination of conformational preferences in unfolded and disordered proteins is an im...
Intrinsically disordered proteins (IDP) are abundant in the human genome and have recently emerged a...
International audienceIntrinsically disordered proteins (IDPs) or intrinsically disordered regions (...
Intrinsically disordered proteins (IDP) are abundant in the human genome and have recently emerged a...
In the post genomic era, as more and more genome sequences are becoming known and hectic efforts are...