Application de MOFs dans l adsorption et libération de molécules d intérêt biologique

The last class of porous materials, organic-inorganic hybrid solids crystalline also commonly called Metal-Organic Frameworks (MOFs) has many advantages for biomedical applications, such as large pore sizes, biodegradability and properties of medical imaging. However, it was proposed to evaluate the cytotoxicity of MOFs with different composition and structure in two different cell lines. We found that MOFs present no or very low cytotoxicity and that depends on the cell line, metal and particle size. Regarding MOFs as controlled drugs release systems, we perfomed a systematic study of the encapsulation and release of model compounds such as caffeine (cosmetics), from a series of MOFs with low toxicity, compositions and topologies different. Results showed that encapsulation and kinetics release of caffeine can be modulated by changing the composition and structure of MOFs. The last approach of this work consisted in forming patches consisting of organic-inorganic hybrid mixtures with the MIL-100 loaded with caffeine and biocompatible polymers for transdermal drug delivery. In vitro release studies showed that the hybrid patches are more effective for slow release caffeine. Studies ex vitro carried out in Ussing chamber showed a greater absorption of caffeine on the skin patch and Gel-CAF somewhat similar in the case of MIL-100-CAF-Gel compared with commercial cream caffeine.VERSAILLES-BU Sciences et IUT (786462101) / SudocSudocFranceF