National audienceTwo paralogous complexes, the proteasome lid and the COP9 signalosome (CSN), have diverged from a common ancestor; yet fulfill distinctive roles within the ubiquitin-proteasome sphere. The CSN regulates the largest family of E3 ubiquitin ligases, called CRLs (Cullin-RING ubiquitin Ligases), while the lid is a subcomplex of the 26S proteasome, a proteolytic machinery responsible for the degradation of ubiquitinated proteins. Remarkably, in many organisms, several subunits of both complexes are duplicated, a circumstance that can hypothetically increase the number of different complexes that can be formed. Duplication, however, is not the only complexity trait within the lid and the CSN, because many of their subunits are not...
The highly conserved COP9 signalosome (CSN) complex is a key regulator of all cullin-RING-ubiquitin ...
The COP9 signalosome (CSN) is a regulator of the ubiquitin (Ub) proteasome system (UPS). In the UPS,...
The COP9 signalosome (CSN) is an evolutionarily conserved protein complex that resembles the lid sub...
National audienceTwo paralogous complexes, the proteasome lid and the COP9 signalosome (CSN), have d...
AbstractThe COP9 signalosome (CSN) is a regulator of the ubiquitin (Ub) proteasome system (UPS). It ...
The COP9 signalosome (CSN) is a regulator of the ubiquitin (Ub) proteasome system (UPS). It interact...
SummaryThe COP9 signalosome (CSN) is an eight-subunit protein complex that is found in all eukaryote...
The COP9 signalosome (CSN) is a conserved protein complex that functions in the ubiquitin-proteasome...
The COP9 signalosome is involved in signal transduction, whereas the 26 S proteasome Lid is a regula...
AbstractThe COP9 signalosome (CSN) is a multiprotein complex of the ubiquitin–proteasome pathway. CS...
SummaryThe highly conserved COP9 signalosome (CSN) complex is a key regulator of all cullin-RING-ubi...
The COP9 signalosome is involved in signal transduction, whereas the 26 S proteasome Lid is a regula...
The COP9 signalosome (CSN) is an evolutionarily conserved multi-protein complex that interfaces with...
AbstractThe proteasome consists of a 20S proteolytic core particle (CP) and a 19S regulatory particl...
SummaryThe evolutionary conserved COP9 signalosome (CSN), a large multisubunit complex, plays a cent...
The highly conserved COP9 signalosome (CSN) complex is a key regulator of all cullin-RING-ubiquitin ...
The COP9 signalosome (CSN) is a regulator of the ubiquitin (Ub) proteasome system (UPS). In the UPS,...
The COP9 signalosome (CSN) is an evolutionarily conserved protein complex that resembles the lid sub...
National audienceTwo paralogous complexes, the proteasome lid and the COP9 signalosome (CSN), have d...
AbstractThe COP9 signalosome (CSN) is a regulator of the ubiquitin (Ub) proteasome system (UPS). It ...
The COP9 signalosome (CSN) is a regulator of the ubiquitin (Ub) proteasome system (UPS). It interact...
SummaryThe COP9 signalosome (CSN) is an eight-subunit protein complex that is found in all eukaryote...
The COP9 signalosome (CSN) is a conserved protein complex that functions in the ubiquitin-proteasome...
The COP9 signalosome is involved in signal transduction, whereas the 26 S proteasome Lid is a regula...
AbstractThe COP9 signalosome (CSN) is a multiprotein complex of the ubiquitin–proteasome pathway. CS...
SummaryThe highly conserved COP9 signalosome (CSN) complex is a key regulator of all cullin-RING-ubi...
The COP9 signalosome is involved in signal transduction, whereas the 26 S proteasome Lid is a regula...
The COP9 signalosome (CSN) is an evolutionarily conserved multi-protein complex that interfaces with...
AbstractThe proteasome consists of a 20S proteolytic core particle (CP) and a 19S regulatory particl...
SummaryThe evolutionary conserved COP9 signalosome (CSN), a large multisubunit complex, plays a cent...
The highly conserved COP9 signalosome (CSN) complex is a key regulator of all cullin-RING-ubiquitin ...
The COP9 signalosome (CSN) is a regulator of the ubiquitin (Ub) proteasome system (UPS). In the UPS,...
The COP9 signalosome (CSN) is an evolutionarily conserved protein complex that resembles the lid sub...