HIV-1 group O infection in Cameroon from 2006 to 2013 : prevalence, genetic diversity, evolution and public health challenges

Villabona-Arenas, C. J.
Domyeum, J.
Mouacha, Fatima
Butel, Christelle
Delaporte, Eric
Peeters, Martine
Mpoudi-Ngole, E.
Aghokeng Fobang, Avelin

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Publication date

January 2015

DOI

10.1016/j.meegid.2015.09.006

ISSN

1567-1348

Citation count (estimate)

Abstract

The human immunodeficiency virus, HIV, is characterized by a tremendously high genetic diversity, leading to the currently known circulating HIV types, groups, subtypes, and recombinant forms. HIV-1 group O is one of the most diverse forms of HIV-1 and has been so far related to Cameroon or individuals originating from Cameroon. In this study, we investigated in Cameroon, the evolution of this viral group from 2006 to 2013, in terms of prevalence, genetic diversity and public health implications. Our results confirmed the predominance of HIV-1 group M (98.5%), a very low prevalence (<0.02%) for HIV-1 group N and P, and HIV-2 in this country. HIV-1 group O was found at around 0.6% (95% confidence interval: 0.4-0.8%), indicating that the freq...